Variable Number Tandem Repeats (VNTRs) consist of repeated DNA sequences of what length?

Prepare for the AAB Molecular Diagnostics Test with focused study materials and practice questions. Gain insights into questions, formats, and key topics to excel in your exam and advance your career in molecular diagnostics.

The correct response is that Variable Number Tandem Repeats (VNTRs) consist of repeated DNA sequences typically ranging from 10 to 50 base pairs in length. VNTRs are a type of repeating sequence in the DNA that vary in tandem repeats among individuals, which makes them useful for genetic fingerprinting and forensics. The variability in the number of tandem repeats in different individuals leads to polymorphism in the DNA, allowing for distinction between different genomes.

The size range of 10 to 50 base pairs is significant as it provides a balance that allows for enough variation to be useful in genetic studies while still being sufficiently short to be easily analyzed using techniques such as polymerase chain reaction (PCR) and capillary electrophoresis. This length range supports the generation of distinct patterns that can serve as genetic markers.

Larger repeat units (such as those exceeding 50 base pairs) are less common in the context of VNTRs and typically fall into a different category of repeats, such as microsatellites. Therefore, understanding the specific size range of VNTRs is crucial for applications in molecular diagnostics and other genetic analyses.

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