What does post-transplant STR PCR analysis determine?

Post-transplant STR (Short Tandem Repeat) PCR (Polymerase Chain Reaction) analysis is utilized primarily to assess the engraftment status of a transplanted graft, such as bone marrow or stem cells. This analysis involves comparing the STR profiles of the donor and recipient cells to evaluate the extent to which the donor cells have incorporated into the recipient's body.

By analyzing the genetic markers, STR PCR can reveal whether the graft has been fully or partially incorporated. A full incorporation typically suggests successful engraftment, where the donor cells have replaced the recipient's bone marrow cells, while partial incorporation may indicate a mixed chimerism scenario where both donor and recipient cells are present. This information is crucial for predicting the outcome of the transplant and planning further management if necessary.

The other options do not pertain directly to what STR PCR analysis measures in the context of transplant. While monitoring donor health or the need for additional treatments may be important aspects of post-transplant care, they are not the primary focus of STR PCR analysis. Similarly, assessing the success of previous bone marrow transplants involves different methodologies that may not specifically rely on STR PCR data. Thus, the determination of whether the graft has been fully or partially incorporated is the pivotal and correct aspect