What is a significant advantage of using long probes in DNA hybridization?

Using long probes in DNA hybridization provides greater specificity in detecting target sequences. This is primarily because longer probes have more binding sites that can complementarily pair with the target DNA, thereby reducing the likelihood of nonspecific binding to similar, but non-target sequences. When hybridization occurs, the longer length helps ensure that the interaction is more stable and unique to the specific sequence of interest. This attribute is particularly beneficial in complex samples where many similar sequences might be present, allowing for clearer and more reliable results in molecular diagnostic applications.

In contrast, other options do not align as closely with the benefits of longer probes. Increased background noise is generally a disadvantage, and the requirement for more DNA would not be a favorable characteristic in this context. While sensitivity to mutations is important, longer probes primarily enhance specificity rather than sensitivity in the detection of single nucleotide variations.