What is one of the most common genetic disorders with an incidence of 1 in 200-400?

Hemochromatosis is a genetic disorder characterized by excessive iron accumulation in the body, which can lead to serious health issues such as liver damage, diabetes, and heart problems. Its prevalence in certain populations, particularly individuals of Northern European descent, is estimated to be around 1 in 200 to 400, making it one of the more common genetic disorders.

This condition is often caused by mutations in the HFE gene, which regulates iron absorption in the intestines. Symptoms may not manifest until adulthood, meaning that it can often go undiagnosed for years, which is why awareness and screening can be essential for those at risk.

In contrast, thalassemia, sickle cell anemia, and cystic fibrosis have different incidences and are more prevalent in specific ethnic groups. Thalassemia mainly affects individuals of Mediterranean, Middle Eastern, or Southeast Asian descent, while sickle cell anemia is most common among people of African, Mediterranean, and Middle Eastern descent. Cystic fibrosis primarily affects individuals of European descent and has a lower incidence compared to hemochromatosis. Each of these conditions has unique genetic underpinnings and clinical presentations, which sets them apart from hemochromatosis in terms of prevalence in the general