Which enzymes are involved in restoring the correct sequence during mismatch repair?

The role of DNA polymerase III in mismatch repair is crucial because this enzyme is responsible for synthesizing new DNA strands. When a mismatch is identified, DNA polymerase III can remove the incorrectly paired nucleotide and replace it with the correct one, ensuring the accuracy of the DNA sequence.

Additionally, DNA ligase plays a significant role in joining the newly synthesized DNA segment back to the existing strand after the mismatch has been corrected. This sealing action is necessary to maintain the integrity of the DNA molecule and ensure that the new and old DNA strands are properly linked.

While other enzymes listed do participate in various DNA repair and replication processes, they do not specifically address the sequence restoration during mismatch repair as directly as DNA polymerase III and ligase do. For example, helicase unwinds the DNA, but it does not contribute to the correction of mismatches. Therefore, the combination of DNA polymerase III for synthesis and ligase for sealing is essential for effectively restoring the correct DNA sequence during the mismatch repair process.