Which of the following is characteristic of dot/blot hybridization?

Dot/blot hybridization is a technique that allows for the study of specific nucleic acid sequences by hybridizing probes to complementary DNA or RNA samples that have been immobilized. The characteristic feature of this technique is that samples are arranged in a geometric array, which facilitates the comparison and analysis of multiple samples simultaneously. This means that scientists can easily visualize and identify distinct spots corresponding to different target nucleic acid sequences on a membrane or solid support.

The geometric array provides a structured format that enhances the precision of detecting and quantifying the hybridization signals. By immobilizing the samples in this way, researchers can apply various probes to the same membrane, allowing for greater efficiency and the ability to analyze multiple targets at once without the need for a separate experiment for each sample.

The other options, while related to molecular hybridization techniques, do not accurately describe the unique characteristics of dot/blot hybridization. For instance, using a single sample at a time does not utilize the full potential of the geometric array feature. Additionally, probes can be placed on various mediums, not exclusively glass slides, and this technique is not limited to DNA as it can also involve RNA and other nucleic acid types.