Which populations have an estimated prevalence of CF mutations lower than the non-Hispanic Caucasian population?

Cystic Fibrosis (CF) is a genetic disorder primarily caused by mutations in the CFTR gene. The prevalence of CF mutations varies significantly among different racial and ethnic groups, largely due to historical and genetic factors.

The non-Hispanic Caucasian population has one of the highest frequencies of CF mutations, with about 1 in 3,000 newborns being affected. In comparison, the Hispanic population has a lower prevalence of CF mutations, estimated to be around 1 in 10,000 to 15,000 newborns, depending on specific subpopulations. Similarly, among African Americans, the prevalence is also lower, with estimates around 1 in 15,000 to 30,000 newborns.

Hence, both the Hispanic and African American populations have a lower estimated prevalence of CF mutations than the non-Hispanic Caucasian population. This makes the option that includes both populations correct, aligning with genetic epidemiology data on the distributions of CF. Understanding these demographic differences is critical in the assessment and screening for cystic fibrosis in diverse populations.